I've had quite good results with airbrushed varnish. Go easy and apply several light, misted-on coats. Too heavy coats can mar the appearance of the pastels (e.g. cause it to all but disappear).
Hand-brushing is a no-no, as it will only cause the pastels to mix with the varnish and flow all over the place.
I don't know about spray varnishes, but I'm sure you'd need to be extra careful to avoid drenching the pastels.